This happened for me after upgrading Ubuntu 12.10 to Ubuntu 13.04.

This appears to be because there is a crash report and Ubuntu is not clearing it.

How to fix System program problem detected error

First you need to open a terminal session then run the following command:

sudo rm /var/crash/*

What that command does is remove all of the old crash reports.

 

If this does not fix the popup then you have a deeper problem and may need to investigate it further.